Quantitative 7T phase imaging in premanifest Huntington disease.

ABSTRACT:

Background and purpose

In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration and atrophy within the striatum of patients with Huntington disease, implicating neuronal loss and iron accumulation in the pathogenesis of this neurodegenerative disorder. We used 7T MR imaging to determine whether quantitative phase, a measurement that reflects both iron content and tissue microstructure, is altered in subjects with premanifest Huntington disease.

Materials and methods

Local field shift, calculated from 7T MR phase images, was quantified in 13 subjects with premanifest Huntington disease and 13 age- and sex-matched controls. All participants underwent 3T and 7T MR imaging, including volumetric T1 and 7T gradient recalled-echo seque

SUBMITTER: Apple AC 

PROVIDER: S-EPMC4425411 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature