Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation.

ABSTRACT:

Background

Several adult stem cell populations exhibit myogenic regenerative potential, thus representing attractive candidates for therapeutic approaches of neuromuscular diseases such as Duchenne Muscular Dystrophy (DMD). We have recently shown that systemic delivery of MuStem cells, skeletal muscle-resident stem cells isolated in healthy dog, generates the remodelling of muscle tissue and gives rise to striking clinical benefits in Golden Retriever Muscular Dystrophy (GRMD) dog. This global effect, which is observed in the clinically relevant DMD animal model, leads us to question here the molecular pathways that are impacted by MuStem cell transplantation. To address this issue, we compare the global gene expression profile between healthy, GRMD and MuStem cell treated GRMD dog

SUBMITTER: Robriquet F 

PROVIDER: S-EPMC4425432 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature