Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition.

ABSTRACT: Tinnitus can occur when damage to the peripheral auditory system leads to spontaneous brain activity that is interpreted as sound [1, 2]. Many abnormalities of brain activity are associated with tinnitus, but it is unclear how these relate to the phantom sound itself, as opposed to predisposing factors or secondary consequences [3]. Demonstrating "core" tinnitus correlates (processes that are both necessary and sufficient for tinnitus perception) requires high-precision recordings of neural activity combined with a behavioral paradigm in which the perception of tinnitus is manipulated and accurately reported by the subject. This has been previously impossible in animal and human research. Here we present extensive intracranial recordings from an awake, behaving tinnitus patient during shor

SUBMITTER: Sedley W 

PROVIDER: S-EPMC4425458 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature