Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control.

ABSTRACT: It is a longstanding question in neuroscience how elaborate multi-joint movements are coordinated coherently. Microzones of cerebellar Purkinje cells (PCs) are thought to mediate this coordination by controlling the timing of particular motor domains. However, it remains to be elucidated to what extent motor coordination deficits can be correlated with abnormalities in coherent activity within these microzones and to what extent artificially evoked synchronous activity within PC ensembles can elicit multi-joint motor behavior. To study PC ensemble correlates of limb, trunk, and tail movements, we developed a transparent disk treadmill that allows quantitative readout of locomotion and posture parameters in head-fixed mice and simultaneous cellular-resolution imaging and/or optogenetic mani

SUBMITTER: Hoogland TM 

PROVIDER: S-EPMC4425462 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature