Transcriptional changes that characterize the immune reactions of leprosy.

ABSTRACT:

Background

Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).

Methods

To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry.

Results

There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the "complement and coagulation" pathway common to both. In

SUBMITTER: Dupnik KM 

PROVIDER: S-EPMC4425823 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature