Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans.

ABSTRACT:

Background

Approximately 8% of the human genome consists of sequences of retroviral origin, a result of ancestral infections of the germ line over millions of years of evolution. The most recent of these infections is attributed to members of the human endogenous retrovirus type-K (HERV-K) (HML-2) family. We recently reported that a previously undetected, large group of HERV-K (HML-2) proviruses, which are descendants of the ancestral K111 infection, are spread throughout human centromeres.

Results

Studying the genomes of certain cell lines and the DNA of healthy individuals that seemingly lack K111, we discover new HERV-K (HML-2) members hidden in pericentromeres of several human chromosomes. All are related through a common ancestor, termed K222, which is a virus that infe

SUBMITTER: Zahn J 

PROVIDER: S-EPMC4425911 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature