Medications as a source of paraben exposure.

ABSTRACT:

Background

Parabens are used as antimicrobial excipients in some pharmaceuticals. Parabens may adversely affect reproduction.

Objectives

Determine whether paraben-containing medication contributes to high urinary paraben concentrations.

Methods

Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples "exposed" and "unexposed" to paraben-containing medication.

Results

Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7h was associated with 8.7-fo

SUBMITTER: Dodge LE 

PROVIDER: S-EPMC4426043 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature