Haptoglobin enhances cardiac transplant rejection.

ABSTRACT:

Rationale

Early graft inflammation enhances both acute and chronic rejection of heart transplants, but it is unclear how this inflammation is initiated.

Objective

To identify specific inflammatory modulators and determine their underlying molecular mechanisms after cardiac transplantation.

Methods and results

We used a murine heterotopic cardiac transplant model to identify inflammatory modulators of early graft inflammation. Unbiased mass spectrometric analysis of cardiac tissue before and ≤72 hours after transplantation revealed that 22 proteins including haptoglobin, a known antioxidant, are significantly upregulated in our grafts. Through the use of haptoglobin-deficient mice, we show that 80% of haptoglobin-deficient recipients treated with perioperative administ

SUBMITTER: Shen H 

PROVIDER: S-EPMC4426092 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature