Binge-like acquisition of 3,4-methylenedioxypyrovalerone (MDPV) self-administration and wheel activity in rats.

ABSTRACT:

Rationale

Lack of access to conventional sources of reinforcement has been proposed as a risk factor for substance abuse in lower socioeconomic populations. There is laboratory evidence that behavioral alternatives (enrichment or exercise) and alternative reinforcers (e.g., sweetened solutions) can reduce self-administration of a variety of drugs.

Objectives

The objective of this study is to determine if drug self-administration could devalue wheel activity in an animal model.

Methods

Male Wistar rats were trained to self-administer 3,4-methylenedioxypyrovalerone (MDPV; "bath salts"), 0.05 mg/kg/infusion, i.v., with concurrent access to a running wheel that was either locked (LW) or unlocked (UW).

Results

MDPV intake steadily increased across the 20-session acq

SUBMITTER: Aarde SM 

PROVIDER: S-EPMC4426253 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature