Differential regulation of antagonistic pleiotropy in synthetic and natural populations suggests its role in adaptation.

ABSTRACT: Antagonistic pleiotropy (AP), the ability of a gene to show opposing effects in different phenotypes, has been identified in various life history traits and complex disorders, indicating its fundamental role in balancing fitness over the course of evolution. It is intuitive that natural selection might maintain AP to allow organisms phenotypic flexibility in different environments. However, despite several attempts, little evidence exists for its role in adaptation. We performed a meta-analysis in yeast to identify the genetic basis of AP in bi-parental segregants, natural isolates, and a laboratory strain genome-wide deletion collection, by comparing growth in favorable and stress conditions. We found that whereas AP was abundant in the synthetic populations, it was absent in the natural

SUBMITTER: Yadav A 

PROVIDER: S-EPMC4426359 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature