Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation.

ABSTRACT: The innate immune system is the first line of defense encountered by invading pathogens. Delayed and/or inadequate innate immune responses can result in failure to combat pathogens, whereas excessive and/or inappropriate responses cause runaway inflammation. Therefore, immune responses are tightly regulated from initiation to resolution and are repressed during the steady state. It is well known that glycans presented on pathogens play important roles in pathogen recognition and the interactions between host molecules and microbes; however, the function of glycans of host organisms in innate immune responses is less well known. Here, we show that innate immune quiescence and strength of the immune response are controlled by host glycosylation involving a novel UDP-galactose transporter cal

SUBMITTER: Yamamoto-Hino M 

PROVIDER: S-EPMC4426399 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature