Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.

ABSTRACT: Intracerebral cell transplantation is being pursued as a treatment for many neurological diseases, and effective cell delivery is critical for clinical success. To facilitate intracerebral cell transplantation at the scale and complexity of the human brain, we developed a platform technology that enables radially branched deployment (RBD) of cells to multiple target locations at variable radial distances and depths along the initial brain penetration tract with real-time interventional magnetic resonance image (iMRI) guidance. iMRI-guided RBD functioned as an "add-on" to standard neurosurgical and imaging workflows, and procedures were performed in a commonly available clinical MRI scanner. Multiple deposits of super paramagnetic iron oxide beads were safely delivered to the striatum of li

SUBMITTER: Silvestrini MT 

PROVIDER: S-EPMC4426791 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature