MiR-382 inhibits osteosarcoma metastasis and relapse by targeting Y box-binding protein 1.

ABSTRACT: Lung metastasis and relapse in osteosarcoma (OS) patients indicate poor prognosis. Here, we identified significantly decreased expression of miR-382 in highly metastatic OS cell lines and relapsed OS samples compared to their parental cell lines and primary OS samples, respectively. In addition, our clinical data showed that the miR-382 expression level was inversely associated with relapse and positively associated with metastasis-free survival in OS patients. The overexpression of miR-382 suppressed epithelial-mesenchymal transition (EMT) and metastasis. This overexpression also decreased the cancer stem cell (CSC) population and function in OS cells. In contrast, inhibition of miR-382 stimulated EMT and metastasis and increased CSC population in OS cells. In addition, our in vivo experi

SUBMITTER: Xu M 

PROVIDER: S-EPMC4426807 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature