Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study.

ABSTRACT:

Background

Numerous experimental studies suggest that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher plasma BNP concentrations have been associated with incident cardiovascular disease and higher left ventricular mass. Genetic association studies may allow us to determine the true causal directions without confounding by compensatory mechanisms.

Methods and results

We performed a meta-analysis of 2 genome-wide association results from a total of 2790 blacks. We assumed an additive genetic model in an association analysis of imputed 2.5 million single-nucleotide polymorphism dosages with residuals generated from multivariable-adjusted logarithmically transformed BNP controlling for relevant covariates and population stratification.

SUBMITTER: Musani SK 

PROVIDER: S-EPMC4426827 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature