Topology-function conservation in protein-protein interaction networks.

ABSTRACT:

Motivation

Proteins underlay the functioning of a cell and the wiring of proteins in protein-protein interaction network (PIN) relates to their biological functions. Proteins with similar wiring in the PIN (topology around them) have been shown to have similar functions. This property has been successfully exploited for predicting protein functions. Topological similarity is also used to guide network alignment algorithms that find similarly wired proteins between PINs of different species; these similarities are used to transfer annotation across PINs, e.g. from model organisms to human. To refine these functional predictions and annotation transfers, we need to gain insight into the variability of the topology-function relationships. For example, a function may be significantly a

SUBMITTER: Davis D 

PROVIDER: S-EPMC4426845 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature