Role of spontaneous physical activity in prediction of susceptibility to activity based anorexia in male and female rats.

ABSTRACT: Anorexia nervosa (AN) is a chronic eating disorder affecting females and males, defined by body weight loss, higher physical activity levels and restricted food intake. Currently, the commonalities and differences between genders in etiology of AN are not well understood. Animal models of AN, such as activity-based anorexia (ABA), can be helpful in identifying factors determining individual susceptibility to AN. In ABA, rodents are given an access to a running wheel while food restricted, resulting in paradoxical increased physical activity levels and weight loss. Recent studies suggest that different behavioral traits, including voluntary exercise, can predict individual weight loss in ABA. A higher inherent drive for movement may promote development and severity of AN, but this hypothesi

SUBMITTER: Perez-Leighton CE 

PROVIDER: S-EPMC4426852 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature