The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.

ABSTRACT:

Objective

To determine whether endometriosis-associated endometrioid cancer (EAOC) is a specific entity compared with endometrioid cancer not associated with endometriosis (OC).

Design

Case-control study.

Setting

University hospital research laboratory.

Patient(s)

Seven patients with endometriosis-associated ovarian cancer EAOC and five patients each with OC, ovarian endometriosis, and benign ovaries.

Intervention(s)

Ovarian tissue samples were collected from surgical procedures.

Main outcome measure(s)

We hybridized cRNA samples to the Affymetrix HG-U133A microarray chip. Representative genes were validated by real time polymerase chain reaction.

Result(s)

We identified two main groups of genes: The first group contained the genes SICA2, C

SUBMITTER: Banz C 

PROVIDER: S-EPMC4426869 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature