Orchestrated triple C-H activation reactions using two directing groups: rapid assembly of complex pyrazoles.

ABSTRACT: A sequential triple C-H activation reaction directed by a pyrazole and an amide group leads to the well-controlled construction of sterically congested dihydrobenzo[e]indazole derivatives. This cascade reaction demonstrates that the often problematic competing C-H activation pathways in the presence of multiple directing groups can be harvested by design to improve step economy in synthesis. Pyrazole as a relatively weak coordinating group is shown to direct Csp3-H activation for the first time.

SUBMITTER: Yang W 

PROVIDER: S-EPMC4426881 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature