Genetic predisposition, nongenetic risk factors, and coronary infarct.

ABSTRACT:

Background

Using a genetic predisposition score (GPS), additively integrating the associations of 11 polymorphisms with coronary heart disease (CHD), we examined the consequences of the joint presence of a high GPS and nongenetic CHD risk factors.

Methods

Within the European Prospective Investigation Into Cancer and Nutrition, 202 case patients with medically confirmed incident coronary infarct and 197 control subjects were identified in Greece. Each polymorphism contributed 1 unit (high-risk homozygous), one-half unit (heterozygous), or no units (low-risk homozygous) to the GPS. Odds ratios of coronary infarction for those at high risk because of genetic predisposition and simultaneous presence of an established CHD risk factor were estimated, compared with subjects at low

SUBMITTER: Trichopoulou A 

PROVIDER: S-EPMC4426987 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature