Metformin in patients with type 2 diabetes and kidney disease: a systematic review.

ABSTRACT:

Importance

Metformin is widely viewed as the best initial pharmacological option to lower glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is contraindicated in many individuals with impaired kidney function because of concerns of lactic acidosis.

Objective

To assess the risk of lactic acidosis associated with metformin use in individuals with impaired kidney function.

Evidence acquisition

In July 2014, we searched the MEDLINE and Cochrane databases for English-language articles pertaining to metformin, kidney disease, and lactic acidosis in humans between 1950 and June 2014. We excluded reviews, letters, editorials, case reports, small case series, and manuscripts that did not directly pertain to the topic area or that met other exc

SUBMITTER: Inzucchi SE 

PROVIDER: S-EPMC4427053 | biostudies-literature | 2014 Dec 24-31

REPOSITORIES: biostudies-literature