Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.

ABSTRACT:

Background

The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies.

Methods and results

We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (n=17 936), African (n=1943), Hispanic (n=795), and Asian (n=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Geno

SUBMITTER: Verhaaren BF 

PROVIDER: S-EPMC4427240 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature