Post-operative plasma osteopontin predicts distant metastasis in human colorectal cancer.

ABSTRACT:

Background

The overall prognosis of colorectal cancer (CRC) patients is unsatisfactory due to cancer metastasis after operation. This study aims to investigate the clinical significance of plasma osteopontin (OPN) levels as minimally invasive, predictive, and surrogate biomarkers for prognosis of CRC patients.

Methods

This randomized study design consists of pre-operative and post-operative plasma samples from a total of 79 patients. We determined plasma levels of OPN by ELISA and examined their correlation with the clinicopathological parameters of CRC patients. The effects of endogenous and exogenous OPN on CRC metastasis were investigated by examination of the effect on regulators of epithelial to messenchymal transition and migration assay.

Results

Our findings de

SUBMITTER: Ng L 

PROVIDER: S-EPMC4427310 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature