Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality.

ABSTRACT:

Objective

We hypothesized that deficiency in 25-hydroxyvitamin D at critical care initiation would be associated with all-cause mortalities.

Design

Two-center observational study.

Setting

Two teaching hospitals in Boston, MA.

Patients

The study included 1,325 patients, age ≥ 18 yrs, in whom 25-hydroxyvitamin D was measured 7 days before or after critical care initiation between 1998 and 2009.

Measurements

25-hydroxyvitamin D was categorized as deficiency in 25-hydroxyvitamin D (≤ 15 ng/mL), insufficiency (16-29 ng/mL), and sufficiency (≥ 30 ng/mL). Logistic regression examined death by days 30, 90, and 365 postcritical care initiation and in-hospital mortality. Adjusted odds ratios were estimated by multivariable logistic regression models.

Interventi

SUBMITTER: Braun AB 

PROVIDER: S-EPMC4427350 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature