ABCB1 C3435T polymorphism is associated with leukemia susceptibility: evidence from a meta-analysis.

ABSTRACT:

Introduction and objective

Many studies have been conducted on the association between the adenosine triphosphate-binding cassette, subfamily B, member 1 (ABCB1) gene C3435T polymorphism and leukemia risk, however, the previously published findings remain controversial. Thus, a meta-analysis was carried out to accurately evaluate the effect of this polymorphism on leukemia susceptibility.

Methods

A computerized literature search was conducted of PubMed, Elsevier database, the China National Knowledge Infrastructure database, and Wanfang Database, to find published case-control studies exploring the relationship between ABCB1 C3435T polymorphism and leukemia risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the strength of association.

Resu

SUBMITTER: Ma L 

PROVIDER: S-EPMC4427449 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature