Extraction of pharmacokinetic evidence of drug-drug interactions from the literature.

ABSTRACT: Drug-drug interaction (DDI) is a major cause of morbidity and mortality and a subject of intense scientific interest. Biomedical literature mining can aid DDI research by extracting evidence for large numbers of potential interactions from published literature and clinical databases. Though DDI is investigated in domains ranging in scale from intracellular biochemistry to human populations, literature mining has not been used to extract specific types of experimental evidence, which are reported differently for distinct experimental goals. We focus on pharmacokinetic evidence for DDI, essential for identifying causal mechanisms of putative interactions and as input for further pharmacological and pharmacoepidemiology investigations. We used manually curated corpora of PubMed abstracts and

SUBMITTER: Kolchinsky A 

PROVIDER: S-EPMC4427505 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature