BrainSignals Revisited: Simplifying a Computational Model of Cerebral Physiology.

ABSTRACT: Multimodal monitoring of brain state is important both for the investigation of healthy cerebral physiology and to inform clinical decision making in conditions of injury and disease. Near-infrared spectroscopy is an instrument modality that allows non-invasive measurement of several physiological variables of clinical interest, notably haemoglobin oxygenation and the redox state of the metabolic enzyme cytochrome c oxidase. Interpreting such measurements requires the integration of multiple signals from different sources to try to understand the physiological states giving rise to them. We have previously published several computational models to assist with such interpretation. Like many models in the realm of Systems Biology, these are complex and dependent on many parameters that can b

SUBMITTER: Caldwell M 

PROVIDER: S-EPMC4427507 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature