Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.

ABSTRACT:

Background

Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma.

Objectives

We sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3.

Methods

We examined associations between 244 independent single nucleotide polymorphisms (SNPs) plus 13 previously identified asthma-related SNPs in the region between 34 and 36 Mb on chromosome 17 and early wheezing phenotypes, doctor-diagnosed asthma and atopy at 7½ years, and bronchial hyperresponsiveness and lung function at 8½ years in 7045 children from the Avon Longitudinal Study of Parents and Children birth cohort study. With this, cis expression quantitative trait loci signals for the sam

SUBMITTER: Granell R 

PROVIDER: S-EPMC4427593 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature