Impact of mechanical activation, scar, and electrical timing on cardiac resynchronization therapy response and clinical outcomes.

ABSTRACT:

Objectives

Using cardiac magnetic resonance (CMR), we sought to evaluate the relative influences of mechanical, electrical, and scar properties at the left ventricular lead position (LVLP) on cardiac resynchronization therapy (CRT) response and clinical events.

Background

CMR cine displacement encoding with stimulated echoes (DENSE) provides high-quality strain for overall dyssynchrony (circumferential uniformity ratio estimate [CURE] 0 to 1) and timing of onset of circumferential contraction at the LVLP. CMR DENSE, late gadolinium enhancement, and electrical timing together could improve upon other imaging modalities for evaluating the optimal LVLP.

Methods

Patients had complete CMR studies and echocardiography before CRT. CRT response was defined as a 15% reduction

SUBMITTER: Bilchick KC 

PROVIDER: S-EPMC4427624 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature