Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies.

ABSTRACT:

Background

Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk.

Methods

Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use.

Findings

During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used h

SUBMITTER: Collaborative Group On Epidemiological Studies Of Ovarian Cancer 

PROVIDER: S-EPMC4427760 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature