Targeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an autoimmune disease in which dysregulated immune cells attack myelin in the central nervous system (CNS), leading to irreversible neuronal degeneration. Our previous studies have demonstrated that epidermal fatty acid binding protein (E-FABP), widely expressed in immune cells, in particular in dendritic cells (DCs) and T lymphocytes, fuels the overactive immune responses in the mouse model of experimental autoimmune encephalomyelitis (EAE).

Methods

In the present study, we conducted an intensive computational docking analysis to identify novel E-FABP inhibitors for regulation of immune cell functions and for treatment of EAE.

Results

We demonstrate that compound [2-(4-acetylphenoxy)-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoqu

SUBMITTER: Rao E 

PROVIDER: S-EPMC4427938 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature