A novel method for identifying disease associated protein complexes based on functional similarity protein complex networks.

ABSTRACT:

Background

Protein complexes formed by non-covalent interaction among proteins play important roles in cellular functions. Computational and purification methods have been used to identify many protein complexes and their cellular functions. However, their roles in terms of causing disease have not been well discovered yet. There exist only a few studies for the identification of disease-associated protein complexes. However, they mostly utilize complicated heterogeneous networks which are constructed based on an out-of-date database of phenotype similarity network collected from literature. In addition, they only apply for diseases for which tissue-specific data exist.

Methods

In this study, we propose a method to identify novel disease-protein complex associations. First,

SUBMITTER: Le DH 

PROVIDER: S-EPMC4427953 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature