Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother.

ABSTRACT:

Background

Current research has led to the appreciation that there are differences in the commensal microbiota between healthy individuals and individuals that are predisposed to disease. Treatments to reverse disease pathogenesis through the manipulation of the gastrointestinal (GI) microbiota are now being explored. Normalizing microbiota between different strains of mice in the same study is also needed to better understand disease pathogenesis. Current approaches require repeated delivery of bacteria and large numbers of animals and vary in treatment start time. A method is needed that can shift the microbiota of predisposed individuals to a healthy microbiota at an early age and sustain this shift through the lifetime of the individual.

Results

We tested cross-fostering

SUBMITTER: Daft JG 

PROVIDER: S-EPMC4427954 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature