Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence.

ABSTRACT:

Background

Streptococcus uberis, a Gram-positive, catalase-negative member of the family Streptococcaceae is an important environmental pathogen responsible for a significant proportion of subclinical and clinical bovine intramammary infections. Currently, the genome of only a single reference strain (0140J) has been described. Here we present a comparative analysis of complete draft genome sequences of an additional twelve S. uberis strains.

Results

Pan and core genome analysis revealed the core genome common to all strains to be 1,550 genes in 1,509 orthologous clusters, complemented by 115-246 accessory genes present in one or more S. uberis strains but absent in the reference strain 0140J. Most of the previously predicted virulent genes were present in the core genome of

SUBMITTER: Hossain M 

PROVIDER: S-EPMC4427978 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature