DisCons: a novel tool to quantify and classify evolutionary conservation of intrinsic protein disorder.

ABSTRACT:

Background

Analyzing the amino acid sequence of an intrinsically disordered protein (IDP) in an evolutionary context can yield novel insights on the functional role of disordered regions and sequence element(s). However, in the case of many IDPs, the lack of evolutionary conservation of the primary sequence can hamper the study of functionality, because the conservation of their disorder profile and ensuing function(s) may not appear in a traditional analysis of the evolutionary history of the protein.

Results

Here we present DisCons (Disorder Conservation), a novel pipelined tool that combines the quantification of sequence- and disorder conservation to classify disordered residue positions. According to this scheme, the most interesting categories (for functional purposes)

SUBMITTER: Varadi M 

PROVIDER: S-EPMC4427981 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature