Computational re-engineering of Amylin sequence with reduced amyloidogenic potential.

ABSTRACT:

Background

The aggregation of amyloid proteins into fibrils is associated with neurodegenerative diseases such as Alzheimer's and Type II Diabetes. Different methods have explored ways to impede and inhibit amyloid aggregation. Most attempts in the literature involve applying stress to the environment around amyloids. Varying pH levels, modifying temperature, applying pressure through protein crowding and ligand docking are classical examples of these methods. However, environmental stress usually affects molecular pathways and protein functions in the cell and is challenging to construct in vivo. In this paper, we explore destabilizing amyloid proteins through the manipulation of genetic code to create beneficial substitute molecules for patients with certain deficiencies.

Resu

SUBMITTER: Smaoui MR 

PROVIDER: S-EPMC4428086 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature