Head injury, potential interaction with genes, and risk for Parkinson's disease.

ABSTRACT:

Introduction

To evaluate the association between head injury and Parkinson's disease (PD), focusing on the timing of head injury, and to explore potential interactions between head injury and genetic factors in PD etiology.

Methods

The analysis included 507 PD cases and 1330 controls, all non-Hispanic Whites. Head injury was retrospectively asked, and genotyping was performed mainly as part of a previous GWAS.

Results

We found a positive association between head injury and PD risk. Compared with no previous head injury, the odds ratio (OR) was 1.39 (95% confidence interval [CI]: 1.00, 1.94) for one and 2.33 (95% CI: 1.25, 4.35) for two or more head injuries (P for trend = 0.0016). We further found that the higher risk was largely attributed to head injuries before age

SUBMITTER: Gao J 

PROVIDER: S-EPMC4428147 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature