A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites.

ABSTRACT:

Background

Filarial nematodes are important pathogens in the tropics transmitted to humans via the bite of blood sucking arthropod vectors. The molecular mechanisms underpinning survival and differentiation of these parasites following transmission are poorly understood. microRNAs are small non-coding RNA molecules that regulate target mRNAs and we set out to investigate whether they play a role in the infection event.

Results

microRNAs differentially expressed during the early post-infective stages of Brugia pahangi L3 were identified by microarray analysis. One of these, bpa-miR-5364, was selected for further study as it is upregulated ~12-fold at 24 hours post-infection, is specific to clade III nematodes, and is a novel member of the let-7 family, which are known to have

SUBMITTER: Winter AD 

PROVIDER: S-EPMC4428239 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature