Approaches for the identification of genetic modifiers of nutrient dependent phenotypes: examples from folate.

ABSTRACT: By combining the sciences of nutrition, bioinformatics, genomics, population genetics, and epidemiology, nutrigenomics is improving our understanding of how diet and nutrient intake can interact with or modify gene expression and disease risk. In this review, we explore various approaches to examine gene-nutrient interactions and the modifying role of nutrient consumption, as they relate to nutrient status and disease risk in human populations. Two common approaches include the use of SNPs in candidate genes to identify their association with nutritional status or disease outcomes, or genome-wide association studies to identify genetic polymorphisms associated with a given phenotype. Here, we examine the results of various gene-nutrient interaction studies, the association of genetic polym

SUBMITTER: Zinck JW 

PROVIDER: S-EPMC4428393 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature