Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators.

ABSTRACT: Biologically active proteins without stable tertiary structure are common in all known proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling, and control. Cellular levels of these important regulators are tightly regulated by a variety mechanisms ranging from firmly controlled expression to precisely targeted degradation. Functions of IDPs are controlled by binding to specific partners, alternative splicing, and posttranslational modifications among other means. In the norm, right amounts of precisely activated IDPs have to be present in right time at right places. Wrecked regulation brings havoc to the ordered world of disordered proteins, leading to protein misfolding, misidentification, and missignaling that give rise to nu

SUBMITTER: Uversky VN 

PROVIDER: S-EPMC4428494 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature