Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation.

ABSTRACT:

Background

miR-137 dysregulation has been implicated in the etiology of schizophrenia, but its functional role remains to be determined.

Methods

Functional magnetic resonance imaging scans were acquired on 48 schizophrenia patients and 63 healthy volunteers (total sample size N = 111 subjects), with similar mean age and sex distribution, while subjects performed a Sternberg Item Response Paradigm with memory loads of one, three, and five numbers. Dorsolateral prefrontal cortex (DLPFC) retrieval activation for the working memory load of three numbers, for which hyperactivation had been shown in schizophrenia patients compared with control subjects, was extracted. The genome-wide association study confirmed schizophrenia risk single nucleotide polymorphism rs1625579 (miR-137 l

SUBMITTER: van Erp TG 

PROVIDER: S-EPMC4428556 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature