Fluorescence lifetime imaging and intravascular ultrasound: co-registration study using ex vivo human coronaries.

ABSTRACT: Fluorescence lifetime imaging (FLIM) has demonstrated potential for robust assessment of atherosclerotic plaques biochemical composition and for complementing conventional intravascular ultrasound (IVUS), which provides information on plaque morphology. The success of such a bi-modal imaging modality depends on accurate segmentation of the IVUS images and proper angular registration between these two modalities. This paper reports a novel IVUS segmentation methodology addressing this issue. The image preprocessing consisted of denoising, using the Wiener filter, followed by image smoothing, implemented through the application of the alternating sequential filter on the edge separability metric images. Extraction of the lumen/intima and media/adventitia boundaries was achieved by tracing th

SUBMITTER: Gorpas D 

PROVIDER: S-EPMC4428614 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature