Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities.

ABSTRACT:

Purpose of review

To summarize current knowledge and provide perspective on relationships between human genetic variants, antiretroviral medications, and aging-related complications of HIV-1 infection.

Recent findings

Human genetic variants have been convincingly associated with interindividual variability in antiretroviral toxicities, drug disposition, and aging-associated complications in HIV-1 infection. Screening for HLA-B5701 to avoid abacavir hypersensitivity reactions has become a routine part of clinical care, and has markedly improved drug safety. There are well established pharmacogenetic associations with other agents (efavirenz, nevirapine, atazanavir, dolutegravir, and others), but this knowledge has yet to have substantial impact on HIV-1 clinical care. As meta

SUBMITTER: Haas DW 

PROVIDER: S-EPMC4428758 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature