Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

ABSTRACT:

Background

Impaired glutamatergic signaling is believed to underlie auditory cortex pyramidal neuron dendritic spine loss and auditory symptoms in schizophrenia. Many schizophrenia risk loci converge on the synaptic glutamate signaling network. We therefore hypothesized that alterations in glutamate signaling protein expression and co-expression network features are present in schizophrenia.

Methods

Gray matter homogenates were prepared from auditory cortex gray matter of 22 schizophrenia and 23 matched control subjects, a subset of whom had been previously assessed for dendritic spine density. One hundred fifty-five selected synaptic proteins were quantified by targeted mass spectrometry. Protein co-expression networks were constructed using weighted gene co-expression netw

SUBMITTER: MacDonald ML 

PROVIDER: S-EPMC4428927 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature