Telomere length variation: A potential new telomere biomarker for lung cancer risk.

ABSTRACT:

Objectives

In this report the associations between telomere length variation (TLV), mean telomere length in blood lymphocytes and lung cancer risk were examined.

Materials and methods

The study design is case-control. Cases (N=191) were patients newly diagnosed with histologically confirmed non-small cell lung cancer. Controls (N=207) were healthy individuals recruited from the same counties as cases and matched to cases on age and gender. Telomere fluorescent in situ hybridization was used to measure telomere features using short-term cultured blood lymphocytes. Logistic regression was used to estimate the strength of association between telomere features and lung cancer risk.

Results

Telomere length variation across all chromosomal ends was significantly associated

SUBMITTER: Sun B 

PROVIDER: S-EPMC4428929 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature