Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo.

ABSTRACT: Current methods for treatment of high-risk neuroblastoma patients include surgical intervention, in addition to systemic chemotherapy. However, only limited therapeutic tools are available to pediatric surgeons involved in neuroblastoma care, so the development of intraoperative treatment modalities is highly desirable. This study presents a silk film library generated for focal therapy of neuroblastoma; these films were loaded with either the chemotherapeutic agent doxorubicin or the targeted drug crizotinib. Drug release kinetics from the silk films were fine-tuned by changing the amount and physical crosslinking of silk; doxorubicin loaded films were further refined by applying a gold nanocoating. Doxorubicin-loaded, physically crosslinked silk films showed the best in vitro activity an

SUBMITTER: Seib FP 

PROVIDER: S-EPMC4428956 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature