Pathways and networks-based analysis of candidate genes associated with nicotine addiction.

ABSTRACT: Nicotine is the addictive substance in tobacco and it has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unclear. Under such situation, a comprehensive analysis focusing on the overall functional characteristics of these genes, as well as how they interact with each other will provide us valuable information to understand nicotine addiction. In this study, we presented a systematic analysis on nicotine addiction-related genes to identify the major underlying biological themes. Functional analysis revealed that biological processes and biochemi

SUBMITTER: Liu M 

PROVIDER: S-EPMC4429103 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature