Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex.

ABSTRACT: The three dimensional conformation of the genome in the cell nucleus influences important biological processes such as gene expression regulation. Recent studies have shown a strong correlation between chromatin interactions and gene co-expression. However, predicting gene co-expression from frequent long-range chromatin interactions remains challenging. We address this by characterizing the topology of the cortical chromatin interaction network using scale-aware topological measures. We demonstrate that based on these characterizations it is possible to accurately predict spatial co-expression between genes in the mouse cortex. Consistent with previous findings, we find that the chromatin interaction profile of a gene-pair is a good predictor of their spatial co-expression. However, the a

SUBMITTER: Babaei S 

PROVIDER: S-EPMC4429121 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature