The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review.

ABSTRACT:

Background

Psychiatric comorbidity is associated with lower quality of life, more fatigue, and reduced adherence to disease-modifying therapy in multiple sclerosis (MS).

Objectives

The objectives of this review are to estimate the incidence and prevalence of selected comorbid psychiatric disorders in MS and evaluate the quality of included studies.

Methods

We searched the PubMed, PsychInfo, SCOPUS, and Web of Knowledge databases and reference lists of retrieved articles. Abstracts were screened for relevance by two independent reviewers, followed by full-text review. Data were abstracted by one reviewer, and verified by a second reviewer. Study quality was evaluated using a standardized tool. For population-based studies we assessed heterogeneity quantitatively using

SUBMITTER: Marrie RA 

PROVIDER: S-EPMC4429164 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature