Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases.

ABSTRACT: Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic signaling pathways; their most highlighted functions include cellular energy generation in the form of adenosine triphosphate (ATP), regulation of cellular calcium homeostasis, balance between ROS production and detoxification, mediation of apoptosis cell death, and synthesis and metabolism of various key molecules. Consistent evidence suggests that mitochondrial failure is associated with early events in the pathogenesis of ageing-related neurodegenerative disorders including Parkinson's disease and Alzheimer's disease. Mitochondria-targeted protective compounds that prevent or minimize mitochondrial dysfunction constitute potential therapeutic strategies in the prevention and treatment of these central ner

SUBMITTER: Fernandez-Moriano C 

PROVIDER: S-EPMC4429198 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature