Alterations in default mode network connectivity during pain processing in borderline personality disorder.

ABSTRACT:

Context

Recent neuroimaging studies have associated activity in the default mode network (DMN) with self-referential and pain processing, both of which are altered in borderline personality disorder (BPD). In patients with BPD, antinociception has been linked to altered activity in brain regions involved in the cognitive and affective evaluation of pain. Findings in healthy subjects indicate that painful stimulation leads to blood oxygenation level-dependent signal decreases and changes in the functional architecture of the DMN.

Objectives

To connect the previously separate research areas of DMN connectivity and altered pain perception in BPD and to explore DMN connectivity during pain processing in patients with BPD.

Design

Case-control study.

Setting

Universi

SUBMITTER: Kluetsch RC 

PROVIDER: S-EPMC4429518 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature